Clinical Trial Network


OBTAIN: The Occurrence of Bleeding and Thrombosis during Antiplatelet therapy In Non-cardiac surgery Study


The OBTAIN study will examine the risks and benefits of continuing antiplatelet treatment in patients presenting for non-cardiac surgery who have one or more coronary artery stents in situ. The risks of perioperative major adverse cardiac events (MACE) in patients who discontinue antiplatelet drugs will be compared with the risk of intraoperative and postoperative bleeding in patients who continue these drugs.

Steering Committee

  • Simon Howell, University of Leeds, United Kingdom
  • Sanne Hoeks, Erasmus University, Rotterdam, Netherlands
  • Stephen Wheatcroft, University of Leeds, United Kingdom
  • Robert West, University of Leeds, United Kingdom
  • Andreas Hoeft, Bonn University, Germany


The study is sponsored  by a grant of the European Society of Anaesthesiology Clinical Trial Network (ESA CTN).

Study is registered on website: NCT01358422

Latest News (30-Apr-2015)

We want to congratulate everyone for their great efforts in data collection and eCRF recording. 847 patients have been entered in OpenClinica, collected by 41 centres in 13 countries. A great achievement! We are very grateful for all your support!

The OBTAIN Statistical Analysis Plan (SAP) v1.0 is available.

Manuscript submission is ongoing



  • Final Protocol: 07 April 2011
  • First subject first visit: 04 October 2011
  • Last subject first visit: 31December 2013
  • Last subject Last visit: 31 January 2014
  • eCRF data entry complete for all centres: 31 March 2014
  • Data Cleaning: February 2014 to January 2015
  • Statistical Analysis Report: June 2015
  • Study Publication: planned 2018



Chief Investigator: 

Dr Simon Howell, University of Leeds, United Kingdom, Sectional of Translational Anaesthetic and Surgical Sciences,  St James’s University Hospital   -

Study coordinator:

 Benoit Plichon,