Clinical Trial Network

SQUEEZE Study : A prospective multi-centre international observational study of postoperative vasopressor use

Chief Investigators

-       Dr. Ib JAMMER (Haukeland University Hospital - Bergen, Norway)

-       Dr. Ben Creagh-Brown (Royal Surrey County Hospital NHS Foundation Trust – Guidlford, United Kingdom)

Download Study Protocol here !

Download Study CRF here ! 

Download Study CRF with comment here ! 

Download the study flyer here

Download the FAQ here ! 

Download the Study Introduction Slides here !

Medical Problem

In the era of goal-directed fluid therapy and increasing popularity of restrictive fluid resuscitation, patients may be receiving less intravenous fluid and receiving more infused vasopressors to maintain adequate blood pressure.

There is anecdotal evidence of substantial variation in the management of post-operative hypotension between centres, countries and continents. The variation is in assessment (cardiac output and invasive monitoring) and environment (post-operative care units, high-dependency units, ICUs) and management (use and choice of fluids and vasopressors/inotropes).

In critically ill populations, receipt of infused vasopressors is associated with organ dysfunction, it has not been established if this relationship is true in postoperative populations.


-       To evaluate the proportion of non-cardiac surgical patients receiving postoperative vasopressors.

-       To evaluate the characteristics of patients, surgery and anaesthesia that lead to postoperative vasopressor use.

-       To evaluate the incidence of organ injury in patients who receive postoperative vasopressors

-       To evaluate the variability in postoperative vasopressor use across healthcare environments.

Outcome Measures

-       Incidence of vasopressor use, and elucidation of risk factors

-       Postoperative organ dysfunction in patients receiving infused vasopressors.


  • Study selected by ESA Research Committee: April 2018
  • Call for centres: Ongoing 
  • Finalizing protocol: Autumn 2018
  • Recruitment of patients: foreseen for Autumn 2019

Join the study

This study will recruit as many participating institutions as possible across the 30 European countries represented at the ESA Council. It is plan to recruit at least 40,000 patients.

Would your hospital like to join this study as an actively contributing research centre? The ‘Call for Centres form’ must be filled in online. The completion of this form will facilitate the coordination and is mandatory for participation in ESA CTN. ESA Secretariat will then contact you providing you with additional information. Please visit the call for centres page

Steering Committee

Ib Jammer (Norway), Ben Creagh-Brown (UK), Lui Forni (UK), Ramani Moonesinghe (UK) and Hannah Wunsch (Canada).

National Coordinating Investigators

The ESA Secretariat and Steering Committee are looking for National Coordinating Investigator to support the conduction of SQUEEZE study, if you are interested, please contact us at


The Study is entirely sponsored by a grant from the European Society of Anaesthesiology Clinical Trial Network (ESA CTN). The aim of the European Society of Anaesthesiology Clinical Trial Network is to provide an infrastructure for clinical research in the fields of Anaesthesia, Pain, Intensive Care and Emergency Medicine by transnational European collaborative studies.

The study is endorsed by the European Society of Intensive Care Medicine (ESICM).

Contact us

European Society of Anaesthesiology

Rue des Comédiens 24
1000 Brussels, Belgium
T: +32 2 743 32 94 / +32 2 210 94 14
F: +32 2 743 32 98